The diabetic foot disease is a potentially dangerous and possibly preventable complication of diabetes mellitus which may result in ulceration, infection, hospitalization, diminished quality of life and amputation of lower limbs. Some of the significant factors leading to development of peripheral neuropathy include peripheral arterial disease, peripheral neuropathy, foot deformities, prior ulceration, inappropriate footwear and poor self care. Prevention then involves conducting early risk screenings of people, regular foot examination, effective glycaemic risk and cardiovascular risk management, education of patients, daily foot checking, proper footwear, and professional intervention in time. Recent guidelines focus more on risk-based screening and combined foot care especially in patients with neuropathy, peripheral artery disease, a history of ulcer, and or an amputation. Assessment of risk, educating and reinforcing self-care practices, and early referral were significantly the functions of nurses and other healthcare professionals. New strategies can be used to support those high-risk patients by using new methods such as home foot-temperature monitoring and other digital health technologies. Altogether, the prevention of diabetic foot necessitates the ongoing cooperation between the patients, their families, and the multidisciplinary healthcare teams. Avoidable complications can also be minimized through regular preventive measures and early detection and treatment of any abnormalities that may lead to complications, and provide mobility and independence to individuals with diabetes to improve their quality of life.